A Digitally Controlled, Remotely Operated ICSI System: Case Report of the First Live Birth
Gerardo Mendizabal-Ruiza, et al, RBMO 2025
This study presents the world’s first successful birth from an automated, remotely controlled intracytoplasmic sperm injection (ICSI) procedure. Roughly half of the micromanipulation steps were performed autonomously by a novel automated system, while the remaining steps involved commands issued remotely by a human operator and executed via a digital interface. Artificial intelligence was also used for tasks such as sperm selection and immobilization. This groundbreaking achievement demonstrates how AI and robotics can move critical parts of fertility treatments away from fully manual processes and reduce operator variability. Ultimately, automation of intricate procedures like ICSI in the IVF laboratory is expected to lead to operator-independent, more predictable outcomes, ease the workload of embryologists, and increase access to quality care for all patients.
